“We are excited to add AM-125 to our development pipeline as it addresses important unmet medical needs in vestibular disorders and serves as a strategic fit with our existing projects,” said Auris Medical’s Founder, Chairman and CEO Thomas Meyer in a press statement. “While oral betahistine has been a mainstay treatment for Ménière’s disease and vestibular vertigo for many years and in many countries around the world, we expect the novel approach of intranasal delivery to offer significant additional benefits in terms of efficacy and tolerability.”
Auris Medical reports that it has entered into an agreement with Otifex Therapeutics Pty Ltd to purchase various assets related to intranasal betahistine, including preclinical and clinical data, as well as certain intellectual property rights. In a Phase 1 trial conducted by Otifex, intranasal betahistine showed good tolerance and a significantly higher bioavailability than reported for oral betahistine administration. Auris Medical plans to initiate a second Phase 1 trial in 2017.
“As our treatment options for vestibular disorders are currently very limited in the United States, I am pleased to see that betahistine will be developed as a treatment for patients here who are suffering from Ménière’s disease or vestibular vertigo,” said Lawrence R. Lustig, MD, Chair, Department of Otolaryngology at Columbia University Medical Center in the press release. “The compound has an established track record for safety, and the clinical experience suggests that it may help control or ease vertigo attacks in Ménière’s disease. It will be exciting to have a new treatment for this disabling condition.”
According to Auris Medical, Betahistine is a small molecule drug that acts as a partial histamine H1-receptor agonist and a H3-receptor antagonist. The compound has demonstrated increased cochlear, vestibular, and cerebral blood flow, vestibular compensation, and the ability to inhibit neuronal firing in the vestibular nuclei.
Oral betahistine is approved for the treatment of Ménière’s disease and vestibular vertigo in more than 80 countries worldwide, and has been reportedly prescribed more than 130 million patients. However, betahistine has not been approved for marketing in the United States for the past few decades.
The brand Serc (betahistine) was approved by the FDA in the early 1970s as vestibular suppressant for Ménière’s disease, but that approval was withdrawn after about 5 years. Primarily, the drug has had issues surrounding its clinical trials and subsequent proof of efficacy. Even though studies have shown betahistine effective against vertigo attacks, most of these studies have been criticized for design flaws. The Cochrane Library concluded in 2001 that “Most trials suggested a reduction of vertigo with betahistine and some suggested a reduction in tinnitus but all these effects may have been caused by bias in the methods. One trial with good methods showed no effect of betahistine on tinnitus compared with placebo in 35 patients. None of the trials showed any effect of betahistine on hearing loss. No serious adverse effects were found with betahistine.”
Update on Auris Medical Tinnitus Trials
Auris Medical also announced last week that it has resumed patient enrollment in the TACTT3 Phase 3 trial of Keyzilen® (AM-101) in acute and post-acute inner ear tinnitus. According to Reuters, the company experienced a set-back in August when the drug missed the main goals of a late-stage study by failing to meet the two co-primary effectiveness goals of statistically significant changes in tinnitus loudness and tinnitus burden compared to a placebo.
“Following the swift approval by regulatory agencies and ethics committees, we are pleased to resume enrollment under the amended protocol in the TACTT3 Phase 3 clinical trial of Keyzilen,” said Meyer. “We have applied key learnings from the TACTT2 trial that we believe substantially strengthen TACTT3’s probability of success, and we look forward to top-line results in early 2018.”
TACTT3, which is being conducted in Europe, is a randomized, double-blind, placebo-controlled Phase 3 trial in inner ear tinnitus following traumatic cochlear injury or otitis media. The trial previously enrolled more than 300 patients during the acute tinnitus stage (Stratum A) and approximately 330 patients during the post-acute tinnitus stage (Stratum B). As previously announced, the TACTT3 protocol was amended based on analysis of the TACTT2 Phase 3 trial outcomes. The amended protocol elevates the Tinnitus Functional Index score from a key secondary endpoint to an alternate primary efficacy endpoint, includes certain patient subgroups in confirmatory statistical testing, and increases the trial size with the enrollment of an additional 60 patients in each of Stratum A and B.
I am a 71 year old Canadian and have suffered from Menderes for a number of years; it had reached the stage where I was flat on my back for almost 36 hrs. Finally got my appointment with a specialist who diagnosed it as meunière and prescribed betahistine as a possible remedy. It helped to lessen the effects for awhile and after a year I was almost back to normal; less ringing in ears, hearing back to normal and no further vertigo symptoms. After a couple of years I cut the dosage to 2 pills per day and a year later to 1 pill, I currently take 1 pill every other day. Hopefully I will reach the stage where it will no longer be required, I am almost reluctant to stop using it and if you have had severe menieres you would understand why. But as far as I am concerned betahistine tablets have been a life saver and I am greatful to my specialist for having recommended it.
Serc is available in Pakistan and fairly cheap. Can’t get by mail.
Had positive effect on my wife’s vertigos. No loss of hearing in either ear. Occasional vertigos and normally when in bed.
We get it when visiting back or through friends.
Thanks for alternative information about drugs online pharmacy in USA. Adhd drugs store is mostly fake but I have find right adhd drugs store in USA,
I’ve been suffering with MD for 20 years. I have been able to control, to some extent, the symptoms with change in diet – Low Sodium, no caffeine, reduced sugar – along with taking a diuretic. Recently, my symptoms have gotten worse with lots of increased pressure, ear ache, head ache, lack of balance, and feeling that at any moment I will have a full blown vertigo attack. My ENT, today, told me about Betahistine. But, that it is not available in the US, and can be purchased with prescription from Canada. We do not have a compounding pharmacy in our area. How do I find a Canadian pharmacy that I can work with through the mail? Also, most of these posts are from 2017, and I am wondering if any progress has been made in the betahistine nasal spray becoming available.
I’m getting mine from North Drug Store in Canada. About $75 for a 90-day supply. My doc sends them the script. Process was very simple.
I get my Serc (brand name) from northdrugstore.com also. 120 tablets are $35 plus $10 for shipping.
I m suffering from suspected menieres disease since 2008 with symptoms of severe vertigo, ear fullness, tinnitus and severe imbalance. In 2012 to November 2016 my all symptoms were cured but after 2016 my symptoms were badly affected once again. I tried all kind of medicines including English medicines and homeopathy but nothing is worked, my vertigo and fullness is severe nowadays. I also feeling sudden loss of balance.
I was diagnosed about 2 years ago, but had symptoms for 2 yrs prior. I was good for about 8 months and now it is starting up again. I also have had drop attacks that are so frightening. I would really appreciate consideration as a participant in the trial. Thank you
I have hydrops cochlearis, which is the small brother of MD. It can be seen on an MRI of the inner ear. This scan is only possible since several months. It is now proven that my inner ear is swollen, causing tinitus, muffled ear, hearing loss and vertigo. I take 9x24mg/day – this high dose is also recently assumed to be good. My ENT is convinced this is the right approach.
Next thing is an steroid injection in my ear.
Hope it helps.
Im a 43 women. Fit, living in the french Pyrenees. I have permanent muffled ear in the left ear and block nose. Originally 5 weeks ago the pressure in my ear was unbearable. I am now on Serc 24mg x2 day. This has helped relieve the pressure but the muffle remains. I have only been on the meds for 1 week.i have stopped talking and dairy and alcohol. I am going to get a night guard as i believe tensing my jaw has/is causing/caused this issue. As well as getting massages for back and neck and seeing a chiropractor for neck. Im trying all this together as i have read on the “my hearing loss blog” about these all helping. Please keep me posted of any developments.
I too have vertigo severe at the moment.on serc 3 times a day.my mood is low and not been able to do my usual activities I also have tinnitus rt was very loud .reassuring there are others like me.
I have had menieres for 24 years. I have periods of several years without vertigo but have been suffering this year again. I now have to wear hearing aids in both ears my left is very poor now. I also have tinnitus. I used to get some warning but now it just happens anywhere anytime. I take 16mg of Serc 3 a day. This helps a bit. I also have Stemetil for vomitting it helps if I can keep it down. There does not appear to be much research into MD. After 24 years nothing much has changed.
My father 69 years
Has meniere since 9 years
Non stop tinnitus
Fullness
Complete hear loss in one ear and the other bad discrimination
Severe vertigo attack in the day
Sounds annoy hom to a great extent
Severe veryigo and motion sickness when taking an escalator
The issue of vertigo is the most annoying, he cant live a normal life
Went to several doctors here in egypt
Called doctors in france
No new news to do
He used to take lots of medicines including betaserc
Stugeron and similar medicines
He took every day several pills of calmepam
In severe cases he takes valiam
What shall we do???
Take additional new medication or any new surgery required putting in consideration that he doesnt want to make the surgeory where he cut the nerve of the ear
Shall he be treated in our country or travel to any plave where there is a better solution
Appreciate answering me as soon as possible
Nadine
I have / was diagnosed with MD some years ago and had spinning vertigo which puts me on the ground with the world spinning around me throwing up, I couldn’t take it, after tests the ENT doc injected Gentamicin in my right ear destroyed yje hearing balance in my right ear since then my vertigo attacks decreased. I still have balance problems and I take SERC 3 times daily he said the brain will adjust. Livable but what choice did I have. I’m now 86 years old. this was done some years ago.
No perfect medicine available on earth. We must wait for intranasal betahistine which may be good for acute vertgo.
Although betahistine is not FDA approved in the U.S., it can be obtained from Canadian pharmacies, less expensive than a U.S. compounding pharmacy. I find taking it twice a day definitely reduces frequency of attacks and woosy symptoms, with no side effects. I find triggers in fatique, dehydration, caffeine, alcohol, heat, and barametric shifts. Crazy life with MD, eh? I would be most interested to try this new approach if a study could include someone in California. Keep searching, your research is appreciated by everyone with MD.
I have had Meniere’s for 10 years. Treatments included trianterene , prednisone & low salt diet. One ENT took me off triamterene and thought it might be migraine related. I was very lucky to be symptom free for 3-4 years. But it has returned with frequent episodes. I sometimes wake up in the middle of the night and get vertigo and have to crawl to the bathroom & vomit for over an hour. Now they are trying steroid shots in the ears. I have major hearing loss in both ears and yes, it changes your life.
Some if the future treatments suggested are gentamicin or surgery to remove the balance organ. But what if you have it in both ears? You can’t have all balance organs removed.
One ENT was about to retire and he told me they don’t know much more about it now than when he graduated from med school.
The specialist I see is 2 hours away.
Depression and tears are becoming a regularity. I am afraid to babysit my granddaughter.
I already participated in a clinical trial and they are suggesting another. I am willing.
I pray for all of you.
I have had menieres since 2010. About 3 years ago I almost always felt dizzy. I finally went to a neurologist who diagnosed the pressure I was feeling above my right eye just before getting dizzy was actually a migraine associated with menieres. He put me on 1000mg of Depakote and I have been able to keep the dizziness away. I need to make sure I get proper rest and I always take naps on the weekends to get my body caught up on sleep. I take the Depakote at night as it can make you sleepy.
Have you tried CBD Oil yet? It has done much for tinnitus and inflammation and dizziness and anxiety without the the levels of Marijuana. Charlotte’s Web is one maker, the other is CBDistillery and now I’m trying a third company joy.im trying different ones because I hear of better results. It’s worth a look. It has helped many.
45M -I lead a technology company and have been battling 4 1/2 yrs. It has absolutely changed the way I work, travel and live. I’ve been in touch with a group in Germany that spins blood and delivers a single shot of serum (Dana White had this done). My vertigo has subsided from yr 1 and 2 however, I constantly feel off and like I’m on the verge. Weather change is a trigger…thanks for sharing updates.
Hi All, well there is a small consolation that I’m not alone. Because Meniere’s makes me feel alone. It seems I’m always trying to explain how I feel to everyone since I look ok. But I don’t feel ok as you all well know. For me, I have really bad aural fullness, jet engine in my head, and awful earaches. When I wake up, I try to face the day positively, and then my feet hit the floor and I start crying. Mostly because I’m mildly lightheaded and off balance 24/7. Did you hear that Huey Lewis from the rock group, Huey Lewis and the News was just diagnosed with MD. Maybe it will get some recognition now.
I’m on Betahistine capsules, 3X a day, for 12 days now. I don’t feel better. Pharmacist said it takes at least 2 weeks to kick in. Well I sure hope we all start to find something that works and glad I found a forum where people understand. Thanks for listening. xo
Chrissey I feel your pain. My mom, my daughter and myself have MD. My life is not the same and people just don’t understand..they think you just eat wrong or did something else to get this. I found hormones and stress are the biggest trigger along with salt. Good luck!
If you are new to this, then Step 1 should be to stop freaking out. If diagnosed with MD, you will get these episodes now and then, you need to accept that and try to move along with this. To further calm you out, everybody in the planet has some or the other problems, our problem is unique in the sense that there is no concrete solution till date. I take Betahistine 16 * 3 and Cinnarizine on need currently and the problem persists.
Please help. Just discovered I have menieres
I have been suffering with MD for 41 years. Was not diagnosed til I was 39. Went to MDs only symptomatic, No one seemed to have a clue,until the son of my PCP,sent me to anENT he had recently graduated with got the ball rolling,and finally got a definitive DX, Have tried all sorts of diets and suggestions anyone could provide. In the early years ,very debilitating and having 3 babies at the same time , no MD thought it was strange that I was crawling around to get through the day and taking care of the children! Valium and some othe med doesn’t always help. Ginger almost always works.w
Would be interested in getting more info on this new study. Oh,and yes I have fullness and tinnitus and moderate hearing loss of the right ear and has started in the left. Seems like my worst enemy is when the barometeric pressure changes!?
What did you mean by “ginger almost always works”?
You don’t have to wait for the intranasal betahistine.
A compounding pharmacy makes my betahistine in pill form. I was completely debilitated by Meziere’s with severe vertigo attacks almost daily until I started betahistine. My attacks are seldom and less severe now. It gave me my life back.
STRONGLY recommend trying it if you have not already. And stay away from salt–max 2 grams a day–and caffeine. Good luck.
I started taking betahistine (8mg 3x daily) two days ago. Don’t notice any difference in my vertigo, fullness, tinnitus. How long did it take to you to notice any improvement?
Hi,
Me too suffering from MD for almost an year now. After 3 ER visits and consulting with ENT doctor he prescribed Betahistine HCl 24mg ,2 time a day. It seems it is not working for me. When this nasal spray will be available?
Thanks
Hi
Betahistine oral tablet is an effective one. Take betahistine 48 mg daily one. If severe episodes take two tablets daily.
Do you live in the United States? I thought this medication is not available in the US.
How many weeks have you been on betahistine? I understand it takes 2 weeks for the drug to kick in.
Someone asked if the drug is available in the US. The answer is yes, at a Compund Pharmacy.
I was diagnosed 4 years ago. Underwent many tests tried the betahistine made me worse. The Dr. And I found the combination of valium, meklizine usual works try to stay sodium, msg,caffeine and sugar free. I do better.but when the weather changes it makes it worse.
I have experienced all the symptoms associated with MD over the past seven years. I had a number of veritgo attacks three years ago but have disappeared until the other day when I had another. It was probably induced by dehydration from skiing and a high salt dinner. I usually monitor my salt intake carefully. I can usually stop the vertigo attacks within 30-40 minutes with 1mg of valium. It has never falied to stop it. THe attacks always seem to leave one unbalanced for a few days. For those times, I just take a small maintenance dose of valium (0.5mg). These are very low doses since the smallest pill is 2mg. It makes a huge difference in day-to-day activities. I have also had about seven intratympanic corticosteriod injections which greatly improve all my symptoms. If you look at the research, you will see that these injections work especially well for veritgo. I am scheduled for another on Tuesday so I can eliminate the valium and hopefully keep anymore vertigo attacks at bay.
Hi Bob, I was considering middle ear steroid injections because my menieres unfortunately is getting worse. Did you have any issues or side effects from the injections?
Thanks.
the injections of dexamethasone WORK… for about 3-4 months then needed again but so what!!They dont hurt that much so go for it!!
I agree with Martha. Dexamethasone injections in the ear worked for me also. I am going to get another round of injections in a couple of weeks. I monitor my sodium intake very carefully and stay well hydrated. I was also on diuretics but stopped when my sodium level was too low on my latest blood work. I think I took it to the extreme with my diet and sodium. Also was on long term antiviral therapy. My Rheumatologit and Otologist don’t agree on anything. I expect to go back on a low dose of diuretics and antiviral med in addition to the transtympanic steroid injections. I would like to never have to take any medications because of side effects no matter how minor. However. some side effects from meds is easier to deal with than Vertigo which is the absolute worst.I will post the results in a couple of weeks. This time I am going to stick it out. Like a lot of people who have posted, I want my life back! Good luck to everyone.
I was diagnosed with Meniere’s in 1999 when the tinnitus began in my left ear and the vertigo followed shortly after. I guess I am considered one of the more fortunate cases because I can go a year or two without the vertigo, but the tinnitus will flare up if I consume too much sodium or caffeine. The most episodes I have had in a year was 77, which was devastating for me, but I hear there are those who have them much more frequently and are unable to work. Although I have experienced vertigo while working and while driving, I have always managed to get myself to a safe place until they subsided. Until last month, I had not had an episode for over 2 years and I was hoping the disease had burned itself out. In fact, I went through some testing and when warm and cold water was injected into the bad ear, nothing happened, but when injected into my good ear, I became dizzy and disoriented. The technician told me that my left ear no longer controlled balance. A couple of weeks ago, I experienced vertigo. It came on quick, but only lasted a couple of minutes. Not sure what that means. I do know that I was diagnosed with Hashimoto’s Thyroiditis and Reynauds at about the same time they discovered the Meniere’s, so I believe this is no coincidence and they are all tied together. I find it hard to believe they haven’t found a cure for this horrible disease and why isn’t it more publicized? I never see anything on Meniere’s, other than what I find on the internet. Please let there be hope for us all very very soon!
I have been experiencing Meniere’s disease for almost 3 years. It started with SSHL in the right ear. I have done just about everything and now I am undergoing a new regimen with a doctor who specializes in treatment.
Life has been difficult and has aged my and changed me . Not for the better! I am trying to stay optimistic and when I cam across your article I really perked up.
Please keep me on the email list for further development. I am going to mention this to my doctor in hopes that a compounding pharmacy will be able to make the pills.
Thank you for all the posts. It helps to have a tribe.
I suffer from menniers & tinnitus.I probably have the worst!It strikes about every other day. Extreme dizziness and vomiting
Sign me up. I suffer from Meniere’s Disease.
I am living with hearing loss and the constant ear muffling + 24/7 tinnitus. The worst of it is Vertigo – delbilitating!
This is a great breakthrough. I am anxious to try it.
For those wishing to obtain the nasal spray, you can have it compounded right now from CareFirst Compounding Pharmacy in New Jersey. I have received it from them. It is advertised on their website.
I have had Sudden Hearing Loss in my left ear for 1 month and would be very interested in hearing more about trials or volunteerng for AM-125
I’m the Associate Principal Horn of the Christchurch Symphony Orchestra, recently diagnosed with Menieres. I have had to voluntarily retire from my position due to this condition.
I hope beyond all hope that it is released soon and would certainly offer myself as a test subject to speed it along, but their contact page doesn’t work correctly.
I am a full-time trumpet player with Meniere’s. Happy to chat about this condition and brass playing.
I have been suffering from this horrible disease for 5 years. i have been on steroid a very low dose to keep me stable, along with vitiams. I am very excited to give this a try. The constant noise in my ear is terrible. I am 45 year old dance teacher with 4 kids and want my life back!
I’m not sure how anyone can tell what treatments work. I am 50 years old,and have had Meniere’s for 17 years. I have full ears and ringing 24/7 and have lost most of the hearing in my left ear. I can live with the hearing loss and the tinnitus, but the vertigo is too much. I still work, but just yesterday had vertigo hit me so hard, and so fast that I had to stop my car and have it towed because I couldn’t drive. I have tried many treatments, including the shunt surgery, and the most recent being chiropractic adjustments to my neck. My vertigo goes away for a while and then always comes back. I never know if a treatment is working or if it is just a coincidence. About six months ago I met with a surgeon about going through with having the nerve cut, but the recovery posts I have read scare me to death. The fear and depression are as bad as the vertigo. Living moment by moment asking yourself 10,000 a day “will it happen now?” is just terrible. I will likely try this next. Good luck to you all!!
Betahistine nasal spray will be available from 2018. This year last quarter last trail will be done. So it is great boon for our minere’society. Once it will come out we can act like normal human being. Let us pray god to come out very fastly.
Are you sure about availability? Reading the article “Auris Medical plans to initiate a second Phase 1 trial in 2017.” How can it progress from phs 1 to approval in 2018? I assume you live in the U.S.
I was diagnosed with Meniere’s in 2005 and have had profound deafness in my left ear since 2007 (and wear a hearing aid). I had been taking just the diuretic and eating a low sodium diet, but had still experienced vertigo often until my ENT prescribed Histamine #2 injections of 0.1 ml./week in 2007. This controlled my vertigo and I have only had 2 slight episodes in 10 years. Up until about 2015, I was able to get a large vial from the hospital pharmacy that lasted approximately 1 year for $11.00. Then the FDA regulated it and I had to start purchasing a 3-month supply for $75 + shipping from a local compounding pharmacy. Now this pharmacy is saying that they cannot get one of the ingredients (components) to make the injection, so they want me to take Betahistine Dihydrochloride pills 3 times/day. So I would be going from a once a week injection to pills 3 times per day (and I’m concerned about getting vertigo again). I am looking for an alternate solution. I would love to just find a compounding pharmacy to make the injectable because that was very easy to me, but I’m wondering if the nasal spray might be a good solution. How often do you have to use it (what is the dosage)? How successful has it been in controlling vertigo? Thanks for any help you can offer.
I have been suffering with severe Menieres in my right hear. I have had two gentamycin injections. The first one lasted about one year, the second one not a long. I am just starting betahistine capsules, 8 mg twice daily. How soon will it take effect? Also, has anyone experienced an increase in urination after starting it?
That will be the diuretic component at work.
Just up your fluid intake a bit.
Great news for us MD suferres! Im in Israel and Serc (=betahistine) is the most common treatment for Meniere. It helped me tremendously for 6 months and now feel a bit off so my ENT increased my dosage.
What is the dose you are taking? i was prescribed 8 mg..
thank you in advance
Kathy
im on 24 mg twice daily
Hi Yael. I am glad to hear the betahistine has worked for you. What disease did your doctor start you on and what is it being increased to? I was just prescribed this medicine and ordering it from Canada. My MD attacks have become so frequent with multiple attacks per week often without any symptomatic warning. Can’t wait to try this stuff!
I’ve had Meniere’s for 37 years and have really struggled with it for the last 2 years. I have a small child and can’t trust myself to look after her, in fear that another attack will leave her unsupervised. There has been no advancement in treating this disease since my father contracted it back in the seventies. I sincerely hope this works.
This is incredibly exciting for all Menieres sufferers however American sufferers have had little to no therapeutic relief. The staple prescribed diuretic is a faux pas and I actually felt embarrassed for my PCP when he prescribed it for me. Didn’t even have it in me to tell him how archaic and useless it was when he was so convinced it was the answer to my problem. Then 2 weeks later had a full blown attack on the diuretic! So much for that! We need this here! Please! I’m an RN and don’t want to lose so much of my hearing that I can’t practice my degree. So many patients here need this!
Agreed, the US needs better treatment options! I’m also an RN and I haven’t been able to work in the past 8 years since my diagnosis. Trying to go to graduate school now for my MSN to hopefully open more options to work despite my disability.
Buy Betahistine from an online pharmacy or have your PMD prescribe it and get it from a Compounding pharmacy. It is approved by FDA to get it through a compounding pharmacy and it is legal to order it online from another country. It just can’t be sold in the US under a brand name and you must have a prescription. I get mine from a friend that lives in Brazil where it is otc. She buys it very cheep and sends it to me. I send her the prescription to make sure there is no issues. Been doing it for years now. Betahistine has helped me 100%!! (I however happen to be one of the few that have responded to it very well). Hope it helps!
Please help I’m 52 male I have 2-4 meneires attacks a week severe virtigo and vomiting usually last from 2 to 8 hours . Lost all hearing in my right ear . I’m to the point of not wanting to live
Craig,please see a doctor for help with depression. I happen to know how you feel, as I have been fighting the vertigo and vomiting too. I have felt like giving up,that death would be better than having these horrific attacks!But there is hope. There will be better days. There are MANY people who understand exactly what you’re going through, and we support each other. Please don’t give up,you are stronger than you think.Praying for strength and comfort for you, friend.
I am making myself think of me nieces attacks n a new way. I have to make myself calm. I am trying to think of them as a season and seasons don’t last long. It’s the worst disease but you r not alone. Shea Ear Clinic in Memphis was awesome. Don’t give up.
You can get SERC betahistine from Canada Drugs by mail order with a prescription.
I had the Gentamicin injections. Killed the hearing in my right ear. Still unbalanced but no Vertigo. Couldn’t take that vertigo, on the floor throwing up. Some folks say, “oh I get dizzy . They don’t know what VERTIGO is really like.
I agree! It has been so progressively debilitating. I finally went back to my ENT and he wrote me an Rx for betahistine to fill at A Canadian pharmacy. Just need your Id , a voided check and the RX and you email it to them. Can’t wait to try it hoping it changes my life! I wish you luck with it. Don’t wait!
Avoid salt and any sodium read all labels no alcohol nicotine chocolate or caffeine, take a water pill and drink LOTS of water don’t let yourself get overheated and take walks but no extreme exercise
Could you please provide a time frame that Betahistine nasal spray would be available in the United States.
Taking betahistine orally since being diagnosed with Menieres in 2008 and find it helpful. I would be interested in an update of availability of betahitine nasal spray. Most serious problem is loss of balance.
I am interested. I have tinitis. Inner ear damage. Doctor said it was from a virus. I Always am unbalanced. I haven’t had a vertigo attach since I gave up salt. I lost 30% hearing about 10 years ago. Then 6 years later boom I got pressure in my ear. Anyway I lost all the hearing. I also can’t hear birds. I can with my right. Wierd. Is this available in canada?
I certainly understand what your going. I’m in the same boat. First attack in Nov. 2008. Then July 2009, this one lasted 5 weeks and was finally diagnosed with meniere’s. I’ve lost almost all of my hearing in my left ear and over 40% in my right ear. My hearing aids help only a little. Fortunately my ENT in Miami, Fl. Has the Betahistine compounded for me. I take 16 mg 3 x daily. It really controls my vertigo. But does nothing for the hearing or tinnitus.
55 yr old active fit wife, mother, Pilates trainer with bilateral Menieres disease. Profound deafness in right ear, current increase in tinnitus and low frequency loss in left ear. Would VERY much like to be included in trial or study group!! Would appreciate receiving any ongoing information regarding this groundbreaking research
Hi Rickie,
I found research papers on-line linking menieres to allergies. This indicated a possible problem with insulin intolerance (and elsewhere that oestrogen levels interacts with insulin) or food allergies. I took both as hypothesis to be tested and through trial and error found the link to milk and marginally higher blood sugar levels when tinitus levels higher, sore eyes, neck pain, dizziness up etc. This was a life saver for me. The betahistine research was at http://www.bmj.com/content/352/bmj.h6816
but my interpretation is that it works for some but potentially makes it worse for others if the root cause of the dizzy spells is allergy or intolerance. I am not an expert just a 58 year old that was determined to understand the condition to get my life back as “the experts” just said no known cause. I hope this helps.
I am very similar to you in that I am bilateral, profoundly deaf in right ear and now tinnitus and low frequency hearing loss in left ear. I am 58 but sadly not as fit as you! I am looking for ways to try to prevent further hearing loss. I have CROS hearing aids which help a bit but cannot give me directional hearing. Cochlear implants can apparently. I have never been prescribed Serc though I have had Menieres off and on for 40 years.
I too am 55 with Meniere’s! Same situation as yours!
A study on betahistine indicated that it did not have a beneficial effect on average. As a previous taker I noticed no benefit, but have friends that swore by it. I then discovered a link between drinking milk and vertigo attacks. betahistine from the documentation can increase your susceptability to allergies. Removing milk & betahistine from my diet has eliminated my mineres, no more vertigo attacks and hearing has returned. My inference is that betahistane can help some but can make it worse for some where an allergy is a root cause.
I have been taking serc during the early stages of my chronic vertigo spinning attacks in 2007. After remaining on a lower maintenance dose for further 2 years the rotational attacks ceased. I now live with permenant tinnitus and unbalance and not used Betahistine for almost 2 years. I am convinced serc really did help my condition by stabilising it. I look forward to using the drug again soon to see if it will improve my coordination/balance and tinnitus especially if the efficacy of the medication is improved using a nasal application. Thank you
Hi
Thank u all I am happy about the medicine when will it be available in Indian market…. Eagerly waiting
I too eagerly waiting for nasal spray. Msy nbe it will take another 1 year according to source.
I am using Serc for the treatment of my Menierse disease and im having very good results . My life has much better quality and i wish Serc was on the PBS in Australia because it is very expensive . I take 3 tables a day and for 24 tablets it cost $30
Its cheaper in Africa,dhl it from there.
How do I get serc? I am on many support groups and several are saying this really helped them and I want to try for I have menieres thanks Linda lyndalou95@icloud would love some info
I would appreciate any information regarding Menieres disease and any therapy available. I have gone thru so many different types of treatments. Do you have any information available. Contact me :
[email protected]
Thanks
If you are in USA you can arrange appointments with specialist in Stanford university or other large hospital. You must get specific test to confirm Meniers.
My husband will be trying beta histamine soon.
Specialist must help you navigate.
Betahistine is not approved here in the US but I order through an international drug company called Pharmacy RX World—$45 for 336 tablets. It takes about 5 weeks to arrive and comes from the UK, Turkey or Ireland. I’ve been ver satisfied with them.
Thanks to this new medicine
I have Ménière’s disease, was diagnosed 6 years ago. I was recently put in betahisine for it because the attacks are getting worse and more frequent. But I am having side effects of the medication. Has anyone taken this medication have any dizziness when just moving your head? It’s totally different from an attack. When I have an attack the vertigo is constant…when I move anything, open my eyes, close my eyes…ect. This is just moving my head…any advice would be appreciative!
Pleased to see advancement of drugs for Meniere
As someone with a vestibular condition and tinnitus, I am happy to hear about these treatments. Currently, I am trying to take betahistine orally, but it upsets my stomach significantly to the point where I am having to reduce my dose and try to work my way up to a therapeutic dose. Having not reached a therapeutic dosage, I don’t even know whether this medication can help me or not. It would be wonderful to have the option of intranasal spray! I am thankful for all who are researching vestibular conditions. Most people know very little about them, including how debilitating they can be. Research is desperately needed. Thank you!